Corpus
The complete Brenner document collection
Primary Sources
The original transcript collection from Sydney Brenner's Web of Stories interviews
Model Distillations
Frontier model analyses of Brenner's methodology - three different perspectives
Final Distillation (GPT-5.2)
GPT-5.2's analysis emphasizing optimization and systematic search.
final_distillation_of_brenner_method_by_gpt_52_extra_high_reasoning.md
Final Distillation (Opus 4.5)
Claude Opus 4.5's analysis framing the method through epistemic axioms.
final_distillation_of_brenner_method_by_opus45.md
Final Distillation (Gemini 3)
Gemini 3's minimal kernel distillation of core cognitive operations.
final_distillation_of_brenner_method_by_gemini3.md
Metaprompts & Reference
Structured prompts and curated quotes for applying the Brenner method
Quote Bank
Curated verbatim quotes organized by theme for quick reference.
quote_bank_restored_primitives.md
Metaprompt (v0.2)
A structured prompt for applying the Brenner method to new domains.
metaprompt_by_gpt_52.md
Initial Metaprompt
The original metaprompt that started the distillation process.
initial_metaprompt.md
Reading Tips
- 1.Start with a Distillation for a structured overview of Brenner's methodology.
- 2.Use the Quote Bank to find specific Brenner quotes on topics of interest.
- 3.Dive into the full Transcript for context and nuance around specific ideas.